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CAS RN: 31637-97-5 | Product Number: E1359
Etofibrate
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Purity: >98.0%(GC)
Synonyms:
- 2-[2-(4-Chlorophenoxy)-2-methyl-1-oxopropoxy]ethyl 3-Pyridinecarboxylate
- 3-Pyridinecarboxylic Acid 2-[2-(4-Chlorophenoxy)-2-methyl-1-oxopropoxy]ethyl Ester
- 2-[[2-(4-Chlorophenoxy)-2-methylpropanoyl]oxy]ethyl Nicotinate
- Nicotinic Acid 2-[[2-(4-Chlorophenoxy)-2-methylpropanoyl]oxy]ethyl Ester
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 50MG |
€110.00
|
Contact Us | 8 |
|
| 250MG |
€352.00
|
Contact Us | 14 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | E1359 |
| Purity / Analysis Method | >98.0%(GC) |
| Molecular Formula / Molecular Weight | C__1__8H__1__8ClNO__5 = 363.79 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 31637-97-5 |
| Reaxys Registry Number | 497931 |
| PubChem Substance ID | 468591729 |
| Merck Index (14) | 3877 |
| MDL Number | MFCD00865727 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(GC) | min. 98.0 % |
| Melting point | 48.0 to 52.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 50 °C |
| Boiling Point | 214 °C/0.3 mmHg |
GHS
Related Laws:
| EC Number | 250-743-1 |
Transport Information:
| HS Number | 2933399990 |
Application
Etofibrate: A Hybrid Hypolipidemic Agent which Combines Nicotinic Acid (Niacin) with Clofibrate
Etofibrate is a hypolipidemic fibrate which combines nicotinic acid (niacin) [N0082] with clofibrate [C0941]. After contact with plasma hydrolases, both active constituents are gradually released in a controlled-release manner. The fibrates, including etofibrate, are lower elevated serum lipids by decreasing the low density lipoprotein (LDL) fraction rich in cholesterol and the very low density lipoprotein (VLDL) fraction rich in triglycerides. In addition, fibrates increase the high density lipoprotein (HDL) cholesterol fraction. (The product is for research purpose only.)
References
- Studies with etofibrate in the rat. Part I: Effects on glycerol, free fatty acid and triacylglycerol metabolism
- Studies with etofibrate in the rat. Part II: a comparison of the effects of prolonged and acute administration on plasma lipids, liver enzymes and adipose tissue lipolysis
- Comparative study on the in vivo and in vitro antilipolytic effects of etofibrate, nicotinic acid and clofibrate in the rat
- High performance liquid chromatographic determination of etofibrate and its hydrolysis products
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