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Published TCIMAIL newest issue No.197
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CAS RN: 522-17-8 | Product Number: D5646
(-)-Deguelin
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Purity: >95.0%(HPLC)
Synonyms:
- (7aS,13aS)-9,10-Dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-pyrano[2,3-c:6,5-f']dichromen-7(7aH)-one
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 50MG |
€457.00
|
Contact Us | 13 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | D5646 |
| Purity / Analysis Method | >95.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__2__3H__2__2O__6 = 394.42 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 522-17-8 |
| Reaxys Registry Number | 1334183 |
| PubChem Substance ID | 468591474 |
| MDL Number | MFCD01740600 |
Specifications
| Appearance | White to Yellow to Green powder to crystal |
| Purity(HPLC) | min. 95.0 area% |
| Specific rotation | -59.0 to -63.0 deg(C=1, methanol) |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 87 °C |
| Maximum Absorption Wavelength | 314(MeOH) nm |
GHS
Related Laws:
| RTECS# | DX1500000 |
Transport Information:
| HS Number | 2932990090 |
Application
Deguelin: a naturally occurring rotenoid and an Akt inhibitor
Deguelin is a naturally occurring rotenoid of the flavonoid family contained in several plant species belonging to the legume family such as Derris trifoliata Lour, and has been used as a naturally occurring insecticide. In vitro and in vivo studies suggests that deguelin exerts potent anticancer activity against multiple cancer types and exhibits chemopreventive potential in Akt-inducible transgenic mouse models. (The product is for research purpose only.)
References
- Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid
- Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis
- Biopharmacological considerations for accelerating drug development of deguelin, a rotenoid with potent chemotherapeutic and chemopreventive potential (a review)
Product Documents (Note: Some products will not have analytical charts available.)
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