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CAS RN: 120011-70-3 | Product Number: D4099
Donepezil Hydrochloride
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Purity: >98.0%(T)(HPLC)
Synonyms:
- 2-(1-Benzyl-4-piperidylmethyl)-5,6-dimethoxy-1-indanone Hydrochloride
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€48.00
|
3 | 7 |
|
| 5G |
€163.00
|
3 | ≥60 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | D4099 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__2__4H__2__9NO__3·HCl = 415.96 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 120011-70-3 |
| Related CAS RN | 120014-06-4 |
| Reaxys Registry Number | 7062905 |
| PubChem Substance ID | 160870963 |
| Merck Index (14) | 3419 |
| MDL Number | MFCD17215939 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
Properties (reference)
| Melting Point | 225 °C |
| Solubility in water | Soluble |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 : Fatal if swallowed. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. P405 : Store locked up. |
Related Laws:
| RTECS# | NK8927885 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | II |
| HS Number | 2933998090 |
Application
Donepezil Hydrochloride: A Reversible Inhibitor of the Enzyme Acetylcholinesterase (AChE).
Donepezil hydrochloride (E2020) is a reversible inhibitor of the enzyme acetylcholinesterase (AChE). Donepezil activates central cholinergic nervous system by increasing the concentration of acetylcholine (ACh) in brain through reversible inhibition of its hydrolysis by acetylcholinesterase. Donepezil hydrochloride is used for the treatment of Alzheimer’s disease. (The product is for research purpose only.)
References
- Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs
- Synthesis and Structure-Activity Relationships of Acetylcholinesterase Inhibitors: 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine Hydrochloride and Related Compounds
- Donepezil hydrochloride (E2020) and other acetylcholinesterase inhibitors (a review)
- Research and development of donepezil hydrochloride, a new type of acetylcholinesterase inhibitor (a review)
- The anti-amnesic and neuroprotective effects of donepezil against amyloid β25-35 peptide-induced toxicity in mice involve an interaction with the σ1 receptor
- A new HPLC method to determine Donepezil hydrochloride in tablets
- Determination of donepezil, an acetylcholinesterase inhibitor, in human plasma by high-performance liquid chromatography with ultraviolet absorbance detection
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