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CAS RN: 13739-02-1 | Product Number: D4061
Diacerein
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Purity: >98.0%(HPLC)
Synonyms:
- 4,5-Diacetoxyanthraquinone-2-carboxylic Acid
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
61,00 €
|
Contact Us | 1 |
|
| 5G |
198,00 €
|
1 | 15 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | D4061 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__9H__1__2O__8 = 368.30 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 13739-02-1 |
| Reaxys Registry Number | 2184909 |
| PubChem Substance ID | 135727331 |
| SDBS (AIST Spectral DB) | 53256 |
| Merck Index (14) | 2960 |
| MDL Number | MFCD00468030 |
Specifications
| Appearance | Light yellow to Amber to Dark green powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(qNMR) | min. 97.0 % |
| Melting point | 241.0 to 245.0 °C |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 243 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| EC Number | 237-310-2 |
| RTECS# | CB8781000 |
Transport Information:
| HS Number | 2918999090 |
Application
Bone research
References
- Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling
- Diacerhein and rhein reduce the ICE-induced IL-1β and IL-18 activation in human osteoarthritic cartilage
Application
Studies on Anti-inflammatory Effect
References
- Diacerhein and rhein reduce the interleukin 1β stimulated inducible nitric oxide synthesis level and activity while stimulating cyclooxygenase-2 synthesis in human osteoarthritic chondrocytes
- J.-P. Pelletier, F. Mineau, J. C. Fernandes, N. Duval, J. Martel-Pelletier, J. Heumatology 1998, 25, 2417.
- Diacerein
- Pharmacological studies of diacerein in animal models of inflammation, arthritis and bone resorption
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