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CAS RN: 196309-76-9 | Product Number: B4845
BAY 11-7085
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Purity: >97.0%(N)
Synonyms:
- (E)-3-(4-tert-Butylphenylsulfonyl)acrylonitrile
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 10MG |
€69.00
|
Contact Us | 11 |
|
| 100MG |
€458.00
|
1 | 10 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | B4845 |
| Purity / Analysis Method | >97.0%(N) |
| Molecular Formula / Molecular Weight | C__1__3H__1__5NO__2S = 249.33 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 196309-76-9 |
| Reaxys Registry Number | 9999499 |
| PubChem Substance ID | 354333080 |
| MDL Number | MFCD01862602 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(with Total Nitrogen) | min. 97.0 % |
| Melting point | 82.0 to 86.0 °C |
Properties (reference)
| Melting Point | 84 °C |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H302 : Harmful if swallowed. H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P270 : Do not eat, drink or smoke when using this product. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P301 + P312 + P330 : IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. |
Related Laws:
| RTECS# | UD1312500 |
Transport Information:
| HS Number | 2930909899 |
Application
Bay 11-7085: An Inhibitor of NFκB and IκBα Phosphorylation
Bay 11-7085 and Bay 11-7082 [T2846] are inhibitors of nuclear factor-κB (NFκB) and phosphorylation of IκBα. They have been shown to inhibit cell proliferation and induce apoptosis of a variety of cells. NFκB is a protein complex controls transcription of DNA and inflammatory cytokine production. Researches demonstrate that inhibition of NFκB can suppress the angiogenic potential and metastasis of cancer cells. IκBα is one member of a family of cellular proteins that function to inhibit the NF-κB transcription factor. In addition, they have anti-inflammatory activity.
References
- An IκBα inhibitor causes leukemia cell death through a p38 MAP kinase-dependent, NF-κB-independent mechanism
- Inhibition of Inhibitor of Nuclear Factor-κB Phosphorylation Increases the Efficacy of Paclitaxel in in Vitro and in Vivo Ovarian Cancer Models
- 15-Deoxy-Δ12,14-prostaglandin J2 inhibits Bay 11-7085-induced sustained extracellular signal-regulated kinase phosphorylation and apoptosis in human articular chondrocytes and synovial fibroblasts
- Nuclear factor-κB inhibitors as sensitizers to anticancer drugs (a review)
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