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CAS RN: 115262-01-6 | Product Number: B4325
(Bromodifluoromethyl)trimethylsilane
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Purity: >98.0%(GC)
Synonyms:
- Bromodifluoro(trimethylsilyl)methane
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
€65.00
|
2 | ≥60 |
|
| 5G |
€206.00
|
1 | ≥80 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | B4325 |
| Purity / Analysis Method | >98.0%(GC) |
| Molecular Formula / Molecular Weight | C__4H__9BrF__2Si = 203.10 |
| Physical State (20 deg.C) | Liquid |
| Storage Temperature | Room Temperature (Recommended in a cool and dark place, <15°C) |
| CAS RN | 115262-01-6 |
| Reaxys Registry Number | 3535353 |
| PubChem Substance ID | 253659955 |
| MDL Number | MFCD18641931 |
Specifications
| Appearance | Colorless to Almost colorless clear liquid |
| Purity(GC) | min. 98.0 % |
Properties (reference)
| Boiling Point | 108 °C |
| Flash point | 17 °C |
| Specific Gravity (20/20) | 1.31 |
| Refractive Index | 1.41 |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H225 : Highly flammable liquid and vapour. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P210 : Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 : Keep container tightly closed. P370 + P378 : In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish. P303 + P361 + P353 : IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water. P403 + P235 : Store in a well-ventilated place. Keep cool. |
Related Laws:
Transport Information:
| UN Number | UN1993 |
| Class | 3 |
| Packing Group | II |
| HS Number | 2931900090 |
Application
An Effective Precursor of a Difluorocarbene to Introduce Difluoromethylene Groups
Difluoromethylenation of alkynes: under a N2 atmosphere, alkynes (0.5 mmol, 1.0 eq.), (bromodifluoromethyl)trimethylsilane (152 mg, 0.75 mmol, 1.5 eq.), tetrabutylammonium bromide (4.8 mg, 0.015 mmol, 0.03 eq.), and toluene (2.0 mL) are added into an oven-dried pressure tube at room temperature. After being heated at 110 °C for 2 h, the reaction mixture is cooled to rt and poured into a saturated Na2CO3 solution (5 mL), followed by extraction with Et2O (2 × 15 mL). The organic layers are combined and dried over anhydrous K2CO3. After the removal of the solvents in vacuo, the residue is subjected to column chromatography (silica gel; petroleum ether : Et3N = 40 : 1) to afford the desired products. [Note: these products are sensitive to acid, so the column must be eluted previously with petroleum ether : Et3N = 10 : 1)].
References
- Synthesis of gem-Difluorocyclopropa(e)nes and O-, S-, N-, and P-Difluoromethylated Compounds with TMSCF2Br
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