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CAS RN: 319460-85-0 | Product Number: A3479

Axitinib


Purity: >95.0%(T)(HPLC)
Synonyms:
  • (E)-N-Methyl-2-[[3-[2-(pyridin-2-yl)vinyl]-1H-indazol-6-yl]thio]benzamide
  • N-Methyl-2-[[3-[(1E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl]sulfanyl]benzamide
Product Documents:
50MG
€166.00
1   18  

*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).


Product Number A3479
Purity / Analysis Method >95.0%(T)(HPLC)
Molecular Formula / Molecular Weight C__2__2H__1__8N__4OS = 386.47 
Physical State (20 deg.C) Solid
Storage Temperature Refrigerated (0-10°C)
Store Under Inert Gas Store under inert gas
Condition to Avoid Air Sensitive,Heat Sensitive
CAS RN 319460-85-0
Reaxys Registry Number 11333336
MDL Number

MFCD09837898

Specifications
Appearance White to Light yellow powder to crystal
Purity(HPLC) min. 95.0 area%
Purity(Nonaqueous Titration) min. 95.0 %
Melting point 217.0 to 221.0 °C
NMR confirm to structure
Properties (reference)
Melting Point 219 °C
Maximum Absorption Wavelength 335(DMSO) nm
Solubility in water Insoluble
GHS
Pictogram Pictogram
Signal Word Warning
Hazard Statements H361 : Suspected of damaging fertility or the unborn child.
Precautionary Statements P501 : Dispose of contents/ container to an approved waste disposal plant.
P202 : Do not handle until all safety precautions have been read and understood.
P201 : Obtain special instructions before use.
P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection.
P308 + P313 : IF exposed or concerned: Get medical advice/ attention.
P405 : Store locked up.
Related Laws:
RTECS# CV5586363
Transport Information:
HS Number 2933399990
Application
Axitinib: A Potent and Selective Inhibitor of VEGFR Tyrosine Kinases -1, -2, and -3

Axitinib (AG-013736), a small molecule indazole derivative, is an oral, potent tyrosine kinase receptor inhibitor, which selectively inhibits vascular endothelial growth factor receptors (VEGFR)-1, -2, and -3. These receptors are implicated in pathologic angiogenesis, tumor growth, and cancer progression. Axitinib is shown to inhibit cellular autophosphorylation of VEGF receptors and tumor growth. (The product is for research purpose only.)

References


Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
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Specifications
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Other Documents

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