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Published TCIMAIL newest issue No.197
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CAS RN: 106941-25-7 | Product Number: A2322
Adefovir
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Purity: >98.0%(T)(HPLC)
Synonyms:
- [2-(6-Aminopurin-9-yl)ethoxymethyl]phosphonic Acid
- 9-[2-(Phosphonomethoxy)ethyl]adenine
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 25G |
€116.00
|
1 | 13 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A2322 |
| Purity / Analysis Method | >98.0%(T)(HPLC) |
| Molecular Formula / Molecular Weight | C__8H__1__2N__5O__4P = 273.19 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (-20°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| CAS RN | 106941-25-7 |
| Reaxys Registry Number | 3561094 |
| Merck Index (14) | 151 |
| MDL Number | MFCD00866943 |
Specifications
| Appearance | White to Light yellow powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Purity(Nonaqueous Titration) | min. 98.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 284 °C |
GHS
Related Laws:
| RTECS# | SZ6563500 |
Transport Information:
| HS Number | 2933599590 |
Application
An Acyclic Nucleotide Analog with Activity against DNA virus
Adefovir (9-(2-phosphonylmethoxyethyl)adenine) is an acyclic nucleotide analog with activity against DNA virus such as human hepatitis B virus (HBV), and an active metabolite of adefovir dipivoxil [A2414] which was developed for clinical use.1) There are reports that adefovir inhibits HBV DNA polymerase (reverse transcriptase) by competing with the natural substrate deoxyadenosine triphosphate and by causing DNA chain termination after its incorporation into viral DNA.2-5) (The product is for research purpose only.)
References
- 1) Clinical pharmacokinetics of the antiviral nucleotide analogs cidofovir and adefovir (a review)
- 2) Metabolic pathways for activation of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine in human lymphoid cells
- 3) Kinetic Interaction of the Diphosphates of 9-(2-phosphonylmethoxyethyl)adenine and Other anti-HIV Active Purine Congeners with HIV Reverse Transcriptase and Human DNA Polymerases α, β and γ
- 4) Mutations in hepatitis B DNA polymerase associated with resistance to lamivudine do not confer resistance to adefovir in vitro
- 5) Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound
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