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Published TCIMAIL newest issue No.197
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CAS RN: 2353-33-5 | Product Number: A2232
5-Aza-2'-deoxycytidine
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Purity:
Synonyms:
- 5-Aza-1-(2-deoxy-β-D-ribofuranosyl)cytosine
- Decitabine
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 20MG |
€55.00
|
1 | 11 |
|
| 100MG |
€189.00
|
1 | ≥40 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A2232 |
| Molecular Formula / Molecular Weight | C__8H__1__2N__4O__4 = 228.21 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container | 100MG-Glass Bottle with Plastic Insert (View image), 20MG-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 2353-33-5 |
| Reaxys Registry Number | 617982 |
| PubChem Substance ID | 160871263 |
| Merck Index (14) | 2853 |
| MDL Number | MFCD00043011 |
Specifications
| Appearance | White to Almost white powder to crystal |
| Elemental analysis(Nitrogen) | 23.8 to 25.0 % |
Properties (reference)
| Melting Point | 191 °C(dec.) |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H341 : Suspected of causing genetic defects. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P202 : Do not handle until all safety precautions have been read and understood. P201 : Obtain special instructions before use. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P405 : Store locked up. |
Related Laws:
| EC Number | 219-089-4 |
| RTECS# | XZ3012000 |
Transport Information:
| HS Number | 2934999090 |
Application
An Inhibitor of DNA Methylation
The cytidine analogs 5-aza-2'-deoxycytidine and 5-azacytidine [A2033] are inhibitors of DNA methyltransferases (DNMTs) which catalyze the transfer of a methyl group to DNA. DNA methylation is an epigenetic factor and plays an important role in regulating gene expression. 5-Azacytidine and 5-aza-2'-deoxycytidine are the currently most advanced agents for epigenetic cancer therapies. (The product is for research purpose only.)
References
- 5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy
- Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells
- Inhibition of DNA methylation by 5-aza-2'-deoxycytidine suppresses the growth of human tumor cell lines
- Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-Aza-2'-deoxycytidine
- Characterization of decomposition products and preclinical and low dose clinical pharmacokinetics of decitabine (5-aza-2'-deoxycytidine) by a new liquid chromatography/tandem mass spectrometry quantification method
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