Published TCIMAIL newest issue No.197
Maximum quantity allowed is 999
Please select the quantity
CAS RN: 1397-89-3 | Product Number: A2114
Amphotericin B
×
![]()
×
Purity: >80.0%(HPLC)
Synonyms:
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 1G |
87,00 €
|
4 | ≥80 |
|
| 5G |
245,00 €
|
Contact Us | ≥100 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | A2114 |
| Purity / Analysis Method | >80.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__4__7H__7__3NO__1__7 = 924.09 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Frozen (<0°C) |
| Store Under Inert Gas | Store under inert gas |
| Condition to Avoid | Air Sensitive,Heat Sensitive |
| Packaging and Container | 1G-Glass Bottle with Plastic Insert (View image) |
| CAS RN | 1397-89-3 |
| Reaxys Registry Number | 4645978 |
| PubChem Substance ID | 468590109 |
| Merck Index (14) | 585 |
| MDL Number | MFCD00877763 |
Specifications
| Appearance | White to Light orange to Yellow powder to crystal |
| Purity(HPLC) | min. 80.0 area% |
| Purity(Volumetric Analysis) | min. 95.0 % |
| IR | confirm to structure |
Properties (reference)
| Melting Point | 170 °C(dec.) |
| Maximum Absorption Wavelength | 408(H2O) nm |
| Solubility in water | Insoluble |
| Degree of solubility in water | 750 mg/l 25 °C |
| Solubility (slightly sol. in) | Methanol |
| Solubility (insoluble in) | Benzene, Ether, Toluene |
GHS
| Pictogram |
|
| Signal Word | Warning |
| Hazard Statements | H315 : Causes skin irritation. H319 : Causes serious eye irritation. |
| Precautionary Statements | P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ eye protection/ face protection. P302 + P352 : IF ON SKIN: Wash with plenty of water. P337 + P313 : If eye irritation persists: Get medical advice/ attention. P362 + P364 : Take off contaminated clothing and wash it before reuse. P332 + P313 : If skin irritation occurs: Get medical advice/ attention. |
Related Laws:
| EC Number | 215-742-2 |
| RTECS# | BU2625000 |
Transport Information:
| HS Number | 2941900000 |
Application
Amphotericin B: A Polyene Macrolide Antifungal Agent
Amphotericin B is a polyene macrolide antifungal agent, and acts by binding to the sterol component, ergosterol, of the cell membrane of susceptible fungi. The mechanisms of action has been reported that it forms transmembrane channels leading to alterations in cell membrane permeability through which monovalent ions (Na+, K+, H+, and Cl-) leak out of the cell resulting in cell death. Amphotericin B shows a high order of in vitro activity against many species of fungi which are all inhibited by concentrations of it ranging from 0.03 to 1.0 μg/mL in vitro. Amphotericin B is also effective against leishmaniasis, a parasitic disease caused by the Leishmania parasite. Recently, in order to improve the tolerability of amphotericin B and reduce toxicity, several formulations, such as liposomal formulations, have been developed. (The product is for research purpose only.)
References
- Amphotericin B: current understanding of mechanisms of action (a review)
- Amphotericin B: new life for an old drug (a review)
- Amphotericin B formulations and drug targeting (a review)
- Amphotericin B Formulations: A Comparative Review of Efficacy and Toxicity
Product Documents (Note: Some products will not have analytical charts available.)
Safety Data Sheet (SDS)
Please select Language.
The requested SDS is not available.
Please Contact Us for more information.
Specifications
C of A & Other Certificates
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
Sample C of A
This is a sample C of A and may not represent a recently manufactured lot of the product.
A sample C of A for this product is not available at this time.
Analytical Charts
Please enter Lot Number
Incorrect Lot Number. Please input only the 4-5 alphanumeric characters before the hyphen.
The requested analytical chart is not available. Sorry for the inconvenience.