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Published TCIMAIL newest issue No.197
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CAS RN: 50-07-7 | Product Number: M2320
Ametycin
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Purity: >98.0%(HPLC)
Synonyms:
- Mitomycin C
Product Documents:
| Size | Unit Price | Belgium | Japan* | Quantity |
|---|---|---|---|---|
| 10MG |
70,00 €
|
2 | ≥80 |
|
| 50MG |
243,00 €
|
6 | 34 |
|
*Stock available in Belgium will be delivered in 1 to 3 days
*Stock available in Japan will be delivered in 1 to 2 weeks (excludes regulated items and dry ice shipments).
| Product Number | M2320 |
| Purity / Analysis Method | >98.0%(HPLC) |
| Molecular Formula / Molecular Weight | C__1__5H__1__8N__4O__5 = 334.33 |
| Physical State (20 deg.C) | Solid |
| Storage Temperature | Refrigerated (0-10°C) |
| Condition to Avoid | Heat Sensitive |
| CAS RN | 50-07-7 |
| Reaxys Registry Number | 3570056 |
| PubChem Substance ID | 172088986 |
| Merck Index (14) | 6215 |
| MDL Number | MFCD00078109 |
Specifications
| Appearance | Dark red to Dark purple to Dark blue powder to crystal |
| Purity(HPLC) | min. 98.0 area% |
| Elemental analysis(Nitrogen) | 16.4 to 17.0 % |
| NMR | confirm to structure |
Properties (reference)
| Melting Point | 64 °C |
GHS
| Pictogram |
|
| Signal Word | Danger |
| Hazard Statements | H300 : Fatal if swallowed. H361 : Suspected of damaging fertility or the unborn child. H351 : Suspected of causing cancer. |
| Precautionary Statements | P501 : Dispose of contents/ container to an approved waste disposal plant. P201 : Obtain special instructions before use. P264 : Wash skin thoroughly after handling. P280 : Wear protective gloves/ protective clothing/ eye protection/ face protection/ hearing protection. P308 + P313 : IF exposed or concerned: Get medical advice/ attention. P301 + P310 + P330 : IF SWALLOWED: Immediately call a POISON CENTER/doctor. Rinse mouth. |
Related Laws:
| EC Number | 200-008-6 |
| RTECS# | CN0700000 |
Transport Information:
| UN Number | UN2811 |
| Class | 6.1 |
| Packing Group | II |
| HS Number | 2941900000 |
Application
Ametycin: A DNA Interstrand Cross-Linking Agent
Ametycin (also known as Mitomycin C) is an antitumor antibiotic and a bifunctional alkylating agent, first isolated from the broth filtrate of Streptomyces caespitosus by Hata et al. (Kitasato Institute) in 1955. Some metabolic activation forms of ametycin inhibit DNA synthesis by causing cross-linking specificity for the sequence CpG. Ametycin causes cell cycle arrest in phase-nonspecific but is most active in S and G phases, and induces apoptosis in cancer cells.
References
- Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA
- DT-diaphorase in activation and detoxification of quinones: bioreductive activation of mitomycin C (a review)
- Mitomycin C: small, fast and deadly (but very selective) (a review)
- The mitomycin bioreductive antitumor agents: crosslinking and alkylation of DNA as the molecular basis of their activity (a review)
- Formation and Repair of Interstrand Cross-Links in DNA (a review)
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